Panama Canal Eastward Cruise 19 Sep, 2025

Cruises & Sailing / Panama

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Amazing Experience

Overview

Cruise Overview 

Enjoy 13 nights of fun and adventure, during your epic getaway. Your cruise kicks off on the incredible Serenade of the Seas and departs from San Diego, California. Your cruise finishes in Miami, Florida, so you may want to plan a couple of extra days to explore this marvelous city.

Highlights

Serenade of the Seas

Oneway From:San Diego, California to Miami, Florida

Visiting:

  • San Diego, California
  • Puerto Vallarta, Mexico
  • Huatulco, Mexico
  • Puntarenas, Costa Rica
  • Panama Canal (Cruising), Panama
  • Cartagena, Colombia
  • Miami, Florida

Departs at 5:00 pm

Downtown bay skyline of San Diego, California

Gaslamp Quarter cityscape with red train in San Diego, California

La Jolla cove beach in San Diego, California

iew of skyline of San Diego, California from Point Loma Island

Balboa Park bell tower in San Diego, California

Beach and Palm Trees in San Diego, California

A cruise from San Diego is always a great idea, because it means you get to start your vacation in a city that’s filled with as much adventure as the destinations you’ll soon sail to. San Diego is nicknamed “America’s Finest City,” and it sure lives up to the title. With its breezy, sunny climate and laid-back, beach-town spirit, this West Coast gem beckons with unique experiences. Before you set out on your cruise out of San Diego, head to the world-famous San Diego Zoo for an up-close look at pandas and Komodo dragons. Sip local brews and savor tasty empanadas outdoors at Liberty Public Market. At the San Diego Museum of Man, a climb to the top of the California Tower will yield dazzling views of the sea, city and bay. And of course, make sure you spend some time at the iconic La Jolla Cove, home to sea lions and an underwater park that’s a favorite destination among snorkelers and divers.

Your ship departs promptly at 5:00 pm, so plan to arrive at least 2-3 hours early to account for checking in and boarding protocols. During this time, many of the ship's amenities are open and operating, so feel free to start your vacation early.

Serenade of the Seas

Family Playing Mini Golf on Liberty of the Seas

 

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Docked from 7:00 am - 4:00 pm

Panoramic view of downtown Puerto Vallarta, Mexico

Las Animas beach in Puerto Vallarta, Mexico

Waterfront malecon in Puerto Vallarta, Mexico

Puerto Vallarta is paradise and romance defined. Relax on pristine beaches such as Yelapa, admire the the terracotta roofs of the old town and take in the impressive views of the bay from its charming promenade. From there, walk down to Los Arcos, the Roman-style arches overlooking the water that are Vallarta's most iconic symbol. Then, head to El Malecon, a beachside walkway with contemporary sculptures, as well as bars, lounges and nightclubs.

Serenade of the Seas

Young Woman Climbing Up the Rock Wall

 

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Docked from 8:00 am - 4:00 pm

A tiki hut with a pair of tanning chairs out on the beach on Huatulco, Mexico

Palm trees along the beach with tiki huts and beach-goers enjoying the day in Huatulco, Mexico

The Catholic Church in Huatulco, Mexico located in the central square

Experience the natural tranquility of the slice of Pacific coast that is Huatulco. Swim in the calms waves at Santa Cruz or La Entrega, or take the 40-minute drive to Barra de la Cruz for picture-perfect surfing. See the world's largest Virgin of Guadaulpe painting at Parroquia de Nuestra Senora de Guadalupe church. Then, refuel with chicken tamales covered with rich mole negro from an authentic street vendor in the old town La Crucecita.

Serenade of the Seas

Family Playing Mini Golf on Liberty of the Seas

 

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Docked from 12:30 pm - 8:00 pm

The rain forest within the Monteverde Cloud Forest in Costa Rica

Public square in Puntarenas, Costa Rica

Pier and Palms in Puntarenas, Costa Rica

Puntarenas introduces you to the ever-beautiful beach attractions of Costa Rica. Drive out to the Nicoya Peninsula and relax on one of its diverse beaches. Journey to the top of active Poas Volcano for incredible views of the turquoise lake that fills its steaming crater. Observe rescued wildlife like jaguars, spider monkeys and electric-colored frogs at La Paz Waterfall Gardens, a private eco-tourism reserve.

Serenade of the Seas

Girls Diving and Swimming in the Covered Pool

 

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Sightseeing from 6:00 am - 3:00 pm

The second lock of the Panama Canal from the Pacific Ocean

An industrial red ship entering the Panama Canal waterway that connects the Atlantic Ocean to the Pacific Ocean

The first lock of the Panama Canal from the Pacific Ocean with a view from a ship

Caupchin monkeys on Monkey Island in Lake Gatun on the Panama Canal

A bridge spanning over the Panama Canal

Jungle on the shoreline of a small island in Lake Gatun, in the Panama Canal, Panama

Cross from one ocean to another while taking in the unparalleled mountain and water views of the engineering marble known as the Panama Canal. The best way for visitors to see the canal is to literally get in the middle of it. See the man-made marvel of the canal while you take in the natural wonders around it, including the rainforest of Soberania National Park and the bright green hilltops of Barro Colorado Island.

Docked from 8:00 am - 4:00 pm

Cartagena, Spain Lighthouse by the Coast

View of a secluded coastal beach in Spain

Cortina Beach in Cartagena, Spain

City hall in Cartagena, Spain

Cartagena de Indias boasts romantic colonial architecture and a Caribbean coast glittering in shades of bright white and aquamarine. Saunter through the leafy Plaza de Bolivar, photographing multicolored streets like Calle Segunda de Badillo. Cruise to Cartagena to dance to the beat of merengue, salsa and Colombia's very own cumbia at places like Bazurto Social Club. Discover Proclamation Square, where the town people gathered in 1811 in support of the declaration of independence from Spain, and walk the 16th-century fortifications of Castillo San Felipe de Barajas. Enjoy Cartagena's natural grandeur on its many beaches, like Bocagrande, Playa Blanca and placid Rosario Islands National Park, just 45 minutes away from the city.

Serenade of the Seas

Young Woman Climbing Up the Rock Wall

 

While at sea, take time to recharge before the next adventure. Lounge by the pool, be spoiled at the spa, dine at any of the onboard restaurants or explore the thrills on each deck until we arrive at the next destination.

Arrives at 5:00 am

Aerial View of South Beach, Miami, Florida

Oleta River State Park Aerial, Miami, Florida

Bill Bags Cape State Park Lighthouse, Miami, Florida

Miami Beach Sandy Beach Sun Ocean

Art Deco Architecture, Miami, Florida

Night life in South Beach, Miami, Florida

Head west of the city for a bike ride past alligators on the Everglades’ Shark Valley route. Take the kids to the Miami Children’s Museum, or paddle a kayak through Biscayne Bay. Come evening, indulge in haute cuisine at a swanky beachside restaurant— all before cocktails and dancing amid The Magic City’s trendy nightlife scene.

The cruise might have ended, but there are still some great activities to enjoy in the area. If you flew into this port, be mindful of your departure flight time and plan accordingly.

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